Detailed view for Bm1_49710

Basic information

TDR Targets ID: 234973
Brugia malayi, TM2 domain containing protein
Source Database / ID:  GenBank

pI: 7.1259 | Length (AA): 518 | MW (Da): 58883 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF05154   TM2 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 312 5dyk (A) 486 800 23.00 0 0.99 0.790217 0.61
5 242 4wih (A) 12 238 26.00 0.000000000012 0.88 0.652359 0.49
8 266 3v8s (A) 40 306 30.00 0 0.74 0.6019 0.86
49 413 4yhj (A) 180 523 23.00 0 1 0.846533 0.38
51 316 5hvj (A) 334 610 25.00 0 1 0.764414 -0.21
62 242 4bf2 (A) 686 880 41.00 0 0.32 0.567321 0.78
114 246 2v62 (A) 103 253 22.00 0.000000000049 0.08 0.250657 0.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133979)

Species Accession Gene Product
Brugia malayi Bm1_49710   TM2 domain containing protein
Caenorhabditis elegans CELE_C41D11.9   Protein C41D11.9
Drosophila melanogaster Dmel_CG12127   almondex
Echinococcus granulosus EgrG_001041500   TM2
Echinococcus multilocularis EmuJ_001041500   TM2
Homo sapiens ENSG00000184277   TM2 domain containing 3
Loa Loa (eye worm) LOAG_00138   STE/STE7 protein kinase
Mus musculus ENSMUSG00000078681   TM2 domain containing 3
Onchocerca volvulus OVOC696   Almondex homolog
Schistosoma japonicum Sjp_0304340   TM2 domain-containing protein 3 precursor, putative
Schistosoma mansoni Smp_054070   hypothetical protein
Trichomonas vaginalis TVAG_258910   conserved hypothetical protein
Trichomonas vaginalis TVAG_309030   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 31.2% 154 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0042 0.5 0.5
0.0093 0.8828 0
0.0067 0.5 0.5
0.0039 0.9485 1
0.0069 0.3067 0.9179
0.0032 0.5 0.5
0.0088 0.4477 0.4477
0.0012 0.5 0.5
0.0016 0.5 0.5
0.0066 0.3101 0
0.0026 0.5 0.5
0.0091 1 1
0.0007 0.5 0.5
0.0059 1 1
0.0059 1 1
0.0039 0.5 0.5
0.0033 0.5 0.5
0.0012 0.5 0.5
0.0081 1 1
0.0092 1 1
0.0036 0.5 0.5
0.0037 1 0.5
0.0029 0.5 0.5
0.0056 1 1
0.0023 0.5 0.5
0.0003 0.5 0.5
0.0027 1 1
0.0016 0.5 0.5
0.0061 0.6883 0.6808
0.0033 1 1
0.0007 0.5 0.5
0.0032 0.5 0.5
0.0007 0.5 0.5
0.0012 0.5 0.5
0.0098 0.3242 0.2614
0.0011 1 1
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0081 0.5 0.5
0.0062 0.6935 0.7231
0.0063 0.7244 0
0.0022 0.5 0.5
0.0063 1 1
0.0064 0.3377 0.3377
0.0018 0.5 0.5
0.0059 1 1
0.0039 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Bm1_49710 (Brugia malayi), TM2 domain containing protein
Title for this comment
Comment